Protein Details: Aquaporin-1

Protein ID

ICDB_Pro_1003

Protein Name

Aquaporin-1

Gene Name

AQP1

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Length

269 amino acids

AlphaFoldDB

AF-Q5R819-F1-model_v4.pdb

Function

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water; thereby permitting water to move in the direction of an osmotic gradient. Component of the ankyrin-1 complex; a multiprotein complex involved in the stability and shape of the erythrocyte membrane.

Sequence

MASEFKKKLFWRAVVAEFLAMTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLPGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDFTDRVKVWTSGQVEEYDLDADDINSRVEMKPK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 56: "Substrate discrimination"; SITE 180: "Substrate discrimination"; SITE 189: "Hg(2+)-sensitive residue"; SITE 195: "Substrate discrimination";

Disease

Location

DOI ID

RefSeq

NP_001126220.1